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Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds
Published on: February 14, 2018
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Antifungal Therapy: New and Evolving Therapies
Yasmine Nivoix1, Marie-Pierre Ledoux2, Raoul Herbrecht2,3
1Department of Pharmacy, Strasbourg University Hospital, Strasbourg, France.
Seminars in Respiratory and Critical Care Medicine
|January 31, 2020
Summary
Invasive fungal diseases are increasing in immunocompromised patients. This review details current antifungal drugs, their mechanisms, spectrum, and side effects to guide treatment choices.
Area of Science:
- Mycology
- Pharmacology
- Infectious Diseases
Background:
- Invasive fungal diseases (IFDs) are a growing concern, particularly in immunocompromised patients due to advancements in medical treatments.
- The availability of effective antifungal agents has historically been limited, necessitating a diverse therapeutic arsenal.
Purpose of the Study:
- To provide a comprehensive overview of currently available antifungal agents for treating IFDs.
- To discuss the mechanisms of action, spectrum of activity, pharmacological properties, drug-drug interactions, and adverse effects of key antifungal classes.
Main Methods:
- Literature review of established and emerging antifungal therapies.
- Analysis of pharmacological data, clinical trial outcomes, and expert guidelines.
Main Results:
- Amphotericin B offers broad-spectrum coverage but has toxicity concerns, especially nephrotoxicity.
- Azoles provide an improved spectrum but require careful management of drug-drug interactions.
- Echinocandins are well-tolerated with fungicidal activity against Candida species but have a narrower spectrum and no oral option.
Conclusions:
- The choice of antifungal agent for IFDs must balance spectrum of activity, tolerability, toxicity, and drug interactions.
- Understanding the pharmacologic profiles of antifungals is crucial for optimizing patient outcomes in this vulnerable population.
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