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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

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Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
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The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Development of Immunocompetence01:22

Development of Immunocompetence

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The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Related Experiment Video

Updated: Dec 29, 2025

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
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Autoinflammatory Disorders with Perinatal Onset.

Nissim G Stolberg1, James W Verbsky1

  • 1Division of Rheumatology, Department of Pediatrics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

Clinics in Perinatology
|February 1, 2020
PubMed
Summary

Autoinflammatory disorders are rare genetic conditions causing inflammation without infection. Early recognition in newborns is crucial for managing complications and initiating targeted therapies.

Keywords:
Autoinflammatory disordersGenetic defectsInfantPerinatal period

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Area of Science:

  • Pediatrics
  • Genetics
  • Immunology

Background:

  • Autoinflammatory disorders are rare genetic conditions characterized by inappropriate inflammation.
  • These disorders can manifest in the perinatal period, presenting diagnostic challenges.
  • Prompt identification is vital due to potential long-term complications and available targeted treatments.

Purpose of the Study:

  • To review the mechanisms of autoinflammatory disorders.
  • To highlight autoinflammatory disorders presenting in the newborn period.
  • To emphasize the importance of recognizing these conditions in neonates.

Main Methods:

  • Literature review of autoinflammatory disorders.
  • Focus on pathophysiologic mechanisms.
  • Identification of neonatal-specific presentations.

Main Results:

  • Autoinflammatory disorders result from genetic defects leading to inflammation.
  • Common presentations include rash, fever, and inflammatory markers.
  • Pathophysiologic understanding guides therapeutic strategies.

Conclusions:

  • Autoinflammatory disorders require careful diagnosis in newborns.
  • Understanding disease mechanisms aids in selecting appropriate therapies.
  • Timely intervention can mitigate long-term sequelae in affected infants.