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Updated: Dec 29, 2025

A Coupled Experiment-finite Element Modeling Methodology for Assessing High Strain Rate Mechanical Response of Soft Biomaterials
Published on: May 18, 2015
Destroy, what destroys you
Khang Luu1,2, Emily Nickles1, Herbert Schwarz1,2
1Department of Physiology, and Immunology Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
New research highlights CD137
Area of Science:
- Immunology and Virology
Background:
- Epstein-Barr virus (EBV) infections are common, and their control is crucial for preventing associated diseases.
- The role of CD137 in EBV infection dynamics and immune response requires further elucidation.
Purpose of the Study:
- To investigate the significance of CD137 in the context of Epstein-Barr virus (EBV) infections.
- To explore the potential of targeting CD137 for therapeutic interventions against EBV-associated conditions.
Main Methods:
- Analysis of genetic mutations in CD137 and their correlation with EBV-associated diseases.
- Investigation of EBV's effect on CD137 expression in relevant cellular contexts.
Main Results:
- Mutations in the CD137 gene are linked to an increased susceptibility to EBV-associated diseases.
- Epstein-Barr virus (EBV) triggers ectopic CD137 expression, leading to negative feedback and reduced T cell costimulation.
Conclusions:
- CD137 plays a critical role in controlling Epstein-Barr virus (EBV) infections.
- CD137 agonists represent a promising therapeutic strategy for treating EBV-associated diseases.
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