Related Experiment Video
Updated: Jun 27, 2026

Transtubular Endoscopic Posterolateral Decompression for L5-S1 Lumbar Lateral Disc Herniation
Published on: October 14, 2022
MRI Radiological Predictors of Requiring Microscopic Lumbar Discectomy After Lumbar Disc Herniation
Christopher G Varlotta1, David H Ge1, Nicholas Stekas1
1Hospital for Joint Diseases, NYU Langone Health, New York, NY, USA.
Study Design:
Retrospective cohort study.
Objective:
To investigate radiological differences in lumbar disc herniations (herniated nucleus pulposus [HNP]) between patients receiving microscopic lumbar discectomy (MLD) and nonoperative patients.
Methods:
Patients with primary treatment for an HNP at a single academic institution between November 2012 to March 2017 were divided into MLD and nonoperative treatment groups. Using magnetic resonance imaging (MRI), axial HNP area; axial canal area; HNP canal compromise; HNP cephalad/caudal migration and HNP MRI signal (black, gray, or mixed) were measured. T test and chi-square analyses compared differences in the groups, binary logistic regression analysis determined odds ratios (ORs), and decision tree analysis compared the cutoff values for risk factors.
Results:
A total of 285 patients (78 MLD, 207 nonoperative) were included. Risk factors for MLD treatment included larger axial HNP area (P < .01, OR = 1.01), caudal migration, and migration magnitude (P < .05, OR = 1.90; P < .01, OR = 1.14), and gray HNP MRI signal (P < .01, OR = 5.42). Cutoff values for risks included axial HNP area (70.52 mm2, OR = 2.66, P < .01), HNP canal compromise (20.0%, OR = 3.29, P < .01), and cephalad/caudal migration (6.8 mm, OR = 2.43, P < .01). MLD risk for those with gray HNP MRI signal (67.6% alone) increased when combined with axial HNP area >70.52 mm2 (75.5%, P = .01) and HNP canal compromise >20.0% (71.1%, P = .05) cutoffs. MLD risk in patients with cephalad/caudal migration >6.8 mm (40.5% alone) increased when combined with axial HNP area and HNP canal compromise (52.4%, 50%; P < .01).
Conclusion:
Patients who underwent MLD treatment had significantly different axial HNP area, frequency of caudal migration, magnitude of cephalad/caudal migration, and disc herniation MRI signal compared to patients with nonoperative treatment.
Insights
Microscopic lumbar discectomy (MLD) patients showed distinct radiological features in herniated nucleus pulposus (HNP) compared to nonoperative cases. These differences, including HNP size and migration, influence treatment decisions for spinal conditions.
Area of Science:
- Neurosurgery
- Radiology
- Orthopedics
Background:
- Lumbar disc herniation (HNP) is a common cause of low back pain.
- Treatment options include microscopic lumbar discectomy (MLD) and nonoperative management.
- Radiological characteristics of HNP may influence treatment selection and outcomes.
Purpose of the Study:
- To compare radiological differences in lumbar disc herniations (HNP) between patients treated with MLD and those managed nonoperatively.
- To identify specific MRI features associated with MLD treatment for HNP.
Main Methods:
- Retrospective cohort study of 285 patients with primary HNP treatment.
- Comparison of MLD and nonoperative groups using MRI parameters: axial HNP area, canal compromise, migration, and MRI signal.
- Statistical analyses included t-tests, chi-square, logistic regression, and decision trees.
Main Results:
- MLD patients had larger axial HNP area, more caudal migration, and different MRI signal characteristics than nonoperative patients.
- Risk factors for MLD included larger HNP area, significant migration, and gray HNP MRI signal.
- Specific cutoff values for HNP area, canal compromise, and migration predicted MLD risk.
Conclusions:
- Significant radiological differences exist in lumbar disc herniations (HNP) between patients undergoing MLD and nonoperative treatment.
- MRI findings such as HNP size, migration patterns, and signal intensity are key differentiators.
- These findings aid in understanding patient selection for MLD versus nonoperative care.
Related Concept Videos
Herniated Intervertebral Disc l: Introduction
Degenerative Disc Disease I: Introduction
Degenerative Disc Disease ll: Pathophysiology

