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Assessment of Child Anthropometry in a Large Epidemiologic Study
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Assessment of Child Anthropometry in a Large Epidemiologic Study

Published on: February 2, 2017

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Increased serum circulating asprosin levels in children with obesity

Eda Sünnetçi Silistre1, Halil Uğur Hatipoğl1

  • 1Department of Pediatrics, Istanbul Training and Education Hospital, İstanbul, Turkey.

Pediatrics International : Official Journal of the Japan Pediatric Society
|February 1, 2020
PubMed

Insights

Childhood obesity is linked to higher serum asprosin levels. This study found significantly elevated asprosin in obese children, suggesting its potential role in pediatric obesity development.

Area of Science:

  • Pediatric Endocrinology
  • Metabolic Research
  • Obesity Studies

Background:

  • Childhood obesity presents a significant global health challenge.
  • Asprosin, a novel adipokine, influences hepatic glucose and insulin regulation during fasting.
  • Understanding factors contributing to pediatric obesity is crucial.

Purpose of the Study:

  • To investigate serum asprosin level differences in children across weight categories: normal, overweight, and obese.
  • To explore the association between asprosin and obesity indicators in children.

Main Methods:

  • Comparative analysis of serum asprosin levels in 44 obese, 54 overweight, and 60 normal weight children.
  • Assessment of anthropometric, biochemical, and hormonal parameters related to obesity.
  • Statistical analysis including post-hoc tests and multiple regression.

Main Results:

  • Serum asprosin levels were significantly elevated in obese children (106.293 ± 122.69 ng/mL) compared to normal weight children (70.903 ± 17.49 ng/mL).
  • Overweight children also showed higher asprosin levels (79.744 ± 29.54 ng/mL) than normal weight children.
  • Asprosin emerged as a significant predictor of obesity in regression analysis.

Conclusions:

  • This study provides the first evidence of increased serum asprosin levels in obese children.
  • Elevated asprosin may play a role in the etiology of childhood obesity.
  • Further research is warranted to elucidate asprosin's function in obesity and associated conditions.
Abstract

Keywords:
AsprosinChildhoodChildrenobesity

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