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Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Overview of Regeneration and Repair01:19

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Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
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Burn Injuries01:22

Burn Injuries

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Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
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Skin Diseases and Disorders01:23

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
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Related Experiment Video

Updated: Dec 29, 2025

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair
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Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair

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Skin ulcers complicating sickle cell disease: an interlinked reparative model.

A Morgante, A Li Destri

    Il Giornale Di Chirurgia
    |February 1, 2020
    PubMed
    Summary

    Sickle cell disease (SCD) can cause chronic skin ulcers, particularly on the lower legs. A combined approach of surgery, advanced medications, and transfusions can successfully heal these difficult ulcers.

    Area of Science:

    • Hematology
    • Dermatology
    • Vascular Medicine

    Background:

    • Skin ulcers are a frequent and debilitating complication of sickle cell disease (SCD), predominantly affecting the lower extremities, especially in homozygous forms.
    • These ulcers result from multifactorial pathogenetic mechanisms, including chronic microvascular disturbances and capillary stasis in areas with limited subcutaneous fat, leading to significant impacts on patient quality of life.

    Observation:

    • The case involves a young woman with severe skin complications secondary to sickle cell disease (drepanocytosis).
    • Her ulcers were chronic, unhealable, and had a significant impact on her pain and psycho-physical well-being, despite previous care attempts.

    Findings:

    • Higher fetal hemoglobin (HbF) concentrations may offer protection against sickle hemoglobin (HbS) polymerization, potentially influencing ulcer healing.

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  • Clinical features of the ulcer were key predictors for determining the optimal treatment strategy.
  • An integrated treatment model combining surgery, advanced medications, and adequate transfusional support, particularly in the early stages, led to successful clinical outcomes.

    • Implications:

    • This case highlights the potential of a multidisciplinary, interlinked reparative model for managing recalcitrant sickle cell-related skin ulcers.
    • Early and adequate transfusional support, alongside surgical and pharmacological interventions, can be crucial for achieving healing in complex cases.
    • Successful management of these ulcers can significantly improve the quality of life for patients suffering from hemoglobinopathies.