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Drug Therapy01:28

Drug Therapy

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The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
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Pharmacokinetics: Drug–Drug Interactions01:25

Pharmacokinetics: Drug–Drug Interactions

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Drug interactions occur when the pharmacological effect of one drug is altered by another substance, either enhancing or diminishing its activity. The drug whose activity is altered is known as the object drug, and the substance causing the alteration is called the agent drug or the precipitant. The net effects of these interactions are mostly undesirable, leading to decreased effectiveness or increased adverse effects. In rare cases, interactions can be beneficial, such as the enhanced...
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Pharmacovigilance01:19

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Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
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Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment01:08

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Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...
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Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Pharmacokinetics: Drug–Food and Drug–Viral Interactions01:26

Pharmacokinetics: Drug–Food and Drug–Viral Interactions

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A drug interaction occurs when the concurrent use of another drug, food, or an external substance alters the pharmacological activity of a drug. This interaction can modify the action of the original drug, affecting its effectiveness and safety.Drug–food interactions are significant as they impact drug absorption, metabolism, and excretion. For example, grapefruit juice is a well-known disruptor of drug metabolism. It inhibits the cytochrome P450 3A4 enzyme, crucial for the metabolism of...
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Adverse Events, Drug Interactions, and Treatment Adherence.

Barbara J Limandri

    Journal of Psychosocial Nursing and Mental Health Services
    |February 1, 2020
    PubMed
    Summary

    Many patients don't take medications as prescribed due to adverse drug effects and interactions. Understanding these issues and patient motivation is key for nurses to improve medication adherence in mental health care.

    Area of Science:

    • Pharmacology
    • Psychiatric Nursing
    • Patient Adherence

    Background:

    • Medication non-adherence is a significant challenge in mental health treatment.
    • Adverse drug effects and drug-drug interactions are common reasons for non-adherence.

    Purpose of the Study:

    • To review adverse drug effects, pharmacokinetics, pharmacodynamics, and drug interactions.
    • To emphasize the role of nurses in assessing and managing these issues to improve patient outcomes.

    Main Methods:

    • Literature review of adverse drug effects and drug interactions.
    • Discussion of pharmacokinetic and pharmacodynamic principles related to adverse effects.
    • Exploration of nursing strategies for patient assessment and medication management.

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    Main Results:

    • Common adverse drug effects and drug-drug interactions can significantly impact medication adherence.
    • Understanding the mechanisms (pharmacokinetics and pharmacodynamics) of these effects is crucial.
    • Nurses play a vital role in identifying, assessing, and managing adverse effects to support adherence.

    Conclusions:

    • Effective management of adverse drug effects and drug interactions is essential for successful mental disorder treatment.
    • Nurses require comprehensive knowledge and assessment skills to address patient concerns and improve medication adherence.
    • Proactive patient assessment and education by nurses can enhance treatment efficacy and patient well-being.