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Published on: September 12, 2016
Moxifloxacin-induced neutropenia in 26-year-old man
Tuğba Kula Atik1, Emre Ispir2, Aykut Aytekin3
1Balıkesir Atatürk City Hospital, Balıkesir, Turkey. tkulaatik@gmail.com.
Abstract:
Moxifloxacin is a fourth generation widely used fluoroquinolone antibiotic. There are three cases of moxifloxacin-induced neutropenia reported in the literature and we report the fourth case. A 26-year-old man with pneumonia was treated with moxifloxacin because of penicillin allergy. On the second day of therapy, leukopenia [White blood cell (WBC) count 2.7×10³/μL] and neutropenia (neutrophils 1.21×10³/μL) occurred. Rothia mucilaginosa was isolated in sputum culture. On the fourth day of hospitalization moxifloxacin treatment was stopped and clarithromycin 500 mg PO twice daily was started. Leukopenia and neutropenia resolved one day after discontinuation of moxifloxacin that WBC and neutrophil count rose 4.5×10³/μL and 1.97×10³/μL, respectively. On the sixth day of hospitalization, WBC and neutrophil count was 4.3×10³/μL and 2.29×10³/μL, respectively. The immunomodulatory effects of moxifloxacin may result in the changes of WBC count like leukopenia with neutropenia. Moxifloxacin induced neutropenia may be more common and is an important adverse effect. More observational studies about safety profiles of moxifloxacin are needed.
Insights
This case report details a fourth instance of moxifloxacin-induced neutropenia. Early discontinuation of this fluoroquinolone antibiotic led to the resolution of leukopenia and neutropenia.
Area of Science:
- Pharmacology
- Infectious Diseases
- Hematology
Background:
- Moxifloxacin is a widely used fourth-generation fluoroquinolone antibiotic.
- Adverse effects of moxifloxacin, particularly neutropenia, require further investigation.
- Previous literature reports three cases of moxifloxacin-induced neutropenia.
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