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Plasma-lactate levels in simulated seizures - An observational study.
Asher Lou Isenberg1, Mikkel Engberg Jensen1, Mette Lindelof1
1Neurological Department, University Hospital of Zealand - Roskilde, Denmark.
Seizure
|February 1, 2020
Summary
Simulated seizures in healthy individuals caused significant increases in plasma lactate levels. These findings suggest that elevated lactate is not a reliable indicator for diagnosing epileptic seizures.
Area of Science:
- Neurology
- Clinical Chemistry
Background:
- Distinguishing epileptic seizures from other conditions like syncope is a diagnostic challenge.
- Plasma lactate has been explored as a biomarker to differentiate seizure types.
Purpose of the Study:
- To investigate plasma lactate levels following simulated non-epileptic seizures.
Main Methods:
- Healthy participants underwent a simulated seizure lasting up to 5 minutes.
- Venous blood samples were collected pre- and post-simulation for lactate and other biochemical analyses.
Main Results:
- The average post-simulation lactate increased from 1.1 to 10.2 mmol/L.
- A significant average increase of 9.1 mmol/L in plasma lactate was observed.
- Average pH decreased from 7.39 to 7.25 post-simulation.
Conclusions:
- High plasma lactate levels after a seizure-like event are not exclusive to epileptic seizures.
- Further research is needed to determine the utility of lactate as a specific marker for epileptic seizures.
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