Related Experiment Video
Updated: Apr 15, 2026

How to Study Placebo Responses in Motion Sickness with a Rotation Chair Paradigm in Healthy Participants
Published on: December 14, 2014
Motion sickness symptoms may be reduced by the Valsalva maneuver: a pilot study
Asher Lou Isenberg1,2, Louie Rogalla1,2, Mads Klokker2,3
1Copenhagen Hearing and Balance Center, Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Copenhagen, Denmark.
Background:
Motion sickness (MS) is a common complaint during most modes of travel. Several medications can be used to treat MS but are often accompanied by side-effects.
Objective:
To assess whether performing the Valsalva manoeuvre can influence the subjective feeling of MS in healthy individuals.
Methods:
We included 16 healthy participants (4 female) that underwent two sessions of MS induction through off-vertical axis rotation (OVAR) using the Epley Omniax Chair. Participants were randomized to do the Valsalva manoeuvre during either their first or second rotation. We assessed MS symptoms using the Motion Sickness Assessment Questionnaire (MSAQ) at baseline (pre-rotation) and at 0-, 10- and 30-minutes post-rotation.
Results:
MS symptoms at 0-minutes post-rotation were significantly lower in participants who did the Valsalva manoeuvre during their first rotation when measured on the MSAQ (p = 0.016). This effect was not present if the Valsalva manoeuvre was done on the second rotation.
Conclusions:
The Valsalva manoeuvre demonstrates potential in mitigating the development of MS symptoms evoked by OVAR.
More Related Videos
06:18Assessing the Autonomic and Behavioral Effects of Passive Motion in Rats using Elevator Vertical Motion and Ferris-Wheel Rotation
Published on: February 7, 2020
07:24Using Eye-tracking to Assess the Relative Importance of Visual and Vestibular Input to Subcortical Motion Processing in the Roll Plane
Published on: August 22, 2025
Related Concept Videos
Cholinergic Antagonists: Pharmacological Actions
Gastrointestinal Effects: Antimuscarinics reduce gut contractions, increase gastric emptying, and slow intestinal transit. They partly inhibit gastric acid secretion...
Cholinergic Antagonists: Therapeutic Uses
Respiratory Tract: Ipratropium, aclidinium, and tiotropium treat asthma, chronic bronchitis, and chronic obstructive pulmonary disease (COPD). They protect against bronchoconstriction caused by irritants like cigarette smoke, sulfur dioxide, and ozone. They also help reduce nasopharyngeal...
Equilibrium and Balance
Pathophysiology of Vomiting
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists
Phenothiazines, such as prochlorperazine...