Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Structural Protein Function01:56

Structural Protein Function

3.1K
3.1K
Structural Protein Function01:56

Structural Protein Function

29.6K
Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity.  In bones and teeth, it mineralizes to...
29.6K
Protein Organization01:24

Protein Organization

8.8K
Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence....
8.8K
Catenins01:23

Catenins

2.9K
Catenins are characterized by multiple binding domains and dynamic structures that allow them to function as linker proteins in cell junction complexes. All catenins, except α-catenin, contain a characteristic protein sequence called the armadillo repeat and are therefore also called armadillo proteins.
Catenins in Cell Junctions
Catenins bind to cell adhesion molecules such as cadherins and link them to different cytoskeletal proteins depending on the type of cell junction. At the...
2.9K
Structure of Cadherins01:25

Structure of Cadherins

4.5K
The cadherins were one of the first cell adhesion molecules discovered; the term “cadherins”   is based on their calcium-dependent adhering properties. The first cadherins discovered on the epithelial, neuronal, and placental cells were named E-cadherin, P-cadherin, and N-cadherin, respectively. These classical cadherins share sequence and structural similarities. Other cadherins, including those involved in cell signaling, are grouped into non-classical cadherins. This...
4.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Modulation of Homer1 EVH1 domain internal dynamics by putative autism-associated mutations.

FEBS letters·2026
Same author

On the state of protein function prediction: a report on the fourth CAFA challenge.

bioRxiv : the preprint server for biology·2026
Same author

Leveraging protein language models and a scoring function for indel characterization and transfer learning.

Patterns (New York, N.Y.)·2026
Same author

Deep learning-assisted tools to understand the structural biology of the synapse.

Biomedical engineering letters·2025
Same author

AlphaFold Protein Structure Database 2025: a redesigned interface and updated structural coverage.

Nucleic acids research·2025
Same author

Structural Modeling and Dynamics of the Full-Length Homer1 Multimer.

Proteins·2025
Same journal

Mapping the 3D Chromosome Organization of a Biosynthetic Gene Cluster by Capture Hi-C (CHi-C).

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Mapping the 3D Chromosome Organization of Streptomyces by Hi-C.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

CUT&Tag Epigenomic Profiling of Biosynthetic Gene Clusters in Arabidopsis thaliana.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Rhizobium rhizogenes-Mediated Hairy Root Transformation Protocol for Lotus japonicus and Other Legumes.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Characterization of Bioactive Saponins from Sea Cucumbers.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Methods for Functional Validation of Terpenoid Metabolic Clusters in Nicotiana benthamiana and Aspergillus oryzae.

Methods in molecular biology (Clifton, N.J.)·2026
See all related articles

Related Experiment Video

Updated: Dec 29, 2025

A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

69.6K

Assessing Protein Function Through Structural Similarities with CATH.

Natalie L Dawson1, Christine Orengo2, Zoltán Gáspári3

  • 1Institute of Structural and Molecular Biology, University College London, London, UK. natalie.dawson.09@ucl.ac.uk.

Methods in Molecular Biology (Clifton, N.J.)
|February 2, 2020
PubMed
Summary
This summary is machine-generated.

Protein structure similarity can reveal functional similarities, even with different functional sites. The CATH database aids in exploring these protein relationships using structural and functional data.

Keywords:
Functional assignmentProtein functionProtein structureStructure classificationStructure similarity

More Related Videos

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins
05:08

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins

Published on: July 8, 2025

834
Analyzing Protein Architectures and Protein-Ligand Complexes by Integrative Structural Mass Spectrometry
07:33

Analyzing Protein Architectures and Protein-Ligand Complexes by Integrative Structural Mass Spectrometry

Published on: October 15, 2018

14.8K

Related Experiment Videos

Last Updated: Dec 29, 2025

A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

69.6K
Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins
05:08

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins

Published on: July 8, 2025

834
Analyzing Protein Architectures and Protein-Ligand Complexes by Integrative Structural Mass Spectrometry
07:33

Analyzing Protein Architectures and Protein-Ligand Complexes by Integrative Structural Mass Spectrometry

Published on: October 15, 2018

14.8K

Area of Science:

  • Structural bioinformatics
  • Protein science
  • Computational biology

Background:

  • Protein function is linked to sequence and structure.
  • Global structural similarity offers insights into protein function.
  • The CATH database classifies protein domain structures and sequences.

Purpose of the Study:

  • To provide an overview of the CATH database.
  • To highlight the use of structural similarity for functional inference.
  • To explain how CATH integrates structural and functional data.

Main Methods:

  • Utilizing the CATH database's hierarchical classification.
  • Analyzing protein domain structures and sequences.
  • Leveraging integrated functional annotations within CATH.

Main Results:

  • CATH classifies over 430,000 protein domain structures.
  • CATH includes nearly 95 million protein domain sequences.
  • Functional annotations are integrated for each protein family.

Conclusions:

  • The CATH database is a valuable resource for understanding protein function.
  • Exploiting structural similarities is key to inferring protein function.
  • CATH facilitates the exploration of structure-function relationships.