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Published on: July 12, 2024
microRNAs expression in relation to particulate matter exposure: A systematic review
Man Cheng1, Bin Wang1, Meng Yang1
1Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Key Laboratory of Environment and Health, Ministry of Education and Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
MicroRNAs (miRNAs) are key epigenetic regulators affected by air pollution. This review summarizes how particulate matter exposure alters miRNAs and impacts health, highlighting the need for further research.
Area of Science:
- Environmental Epigenetics
- Molecular Biology
- Toxicology
Background:
- MicroRNAs (miRNAs) are small, non-coding RNAs regulating gene expression and cellular processes.
- Air pollution, particularly particulate matter (PM), can induce epigenetic changes.
- miRNAs are increasingly recognized as mediators linking PM exposure to adverse health outcomes.
Purpose of the Study:
- To review current knowledge on miRNA expression changes in response to particulate matter exposure.
- To explore the functions of altered miRNAs and their potential biological mechanisms in PM-induced health effects.
- To identify knowledge gaps and suggest future research directions.
Main Methods:
- Systematic review of epidemiological and experimental studies.
- Categorization of studies based on particulate matter size and source.
- Analysis of miRNA functions and predicted biological pathways.
Main Results:
- Particulate matter exposure significantly alters miRNA expression profiles.
- Altered miRNAs are implicated in various PM-induced health effects, including inflammation and cardiovascular issues.
- Specific miRNAs and their regulatory pathways are associated with PM exposure.
Conclusions:
- miRNAs serve as crucial biomarkers and mediators in the context of air pollution exposure.
- Understanding PM-miRNA interactions is vital for elucidating environmental disease etiology.
- Further rigorous studies are needed to fully comprehend the role of PM in miRNA alterations and subsequent health impacts.
