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Chirality

Chirality

Chirality is a term that describes the lack of mirror symmetry in an object. In other words, chiral objects cannot be superposed on their mirror images. For example, our feet are chiral, as the mirror image of the left foot, the right foot, cannot be superposed on the left foot.
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...

Chirality in Nature

Chirality in Nature

Chirality is the most intriguing yet essential facet of nature, governing life’s biochemical processes and precision. It can be observed from a snail shell pattern in a macroscopic world to an amino acid, the minutest building block of life. Most of the snails around the world have right-coiled shells because of the intrinsic chirality in their genes. All the amino acids present in the human body exist in an enantiomerically pure state, except for glycine - the sole achiral amino acid.

Molecules with Multiple Chiral Centers

Molecules with Multiple Chiral Centers

Molecules that possess multiple chiral centers can afford a large number of stereoisomers. For instance, while some molecules like 2-butanol have one chiral center, defined as a tetrahedral carbon atom with four different substituents attached, several molecules like butane-2,3-diol have multiple chiral centers. A simple formula to predict the number of stereoisomers possible for a molecule with n chiral centers is 2n. However, there can be a lower number where some of the stereoisomers are...

Prochirality

Prochirality

The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...

Chirality at Nitrogen, Phosphorus, and Sulfur

Chirality at Nitrogen, Phosphorus, and Sulfur

Chirality is most prevalent in carbon-based tetrahedral compounds, but this important facet of molecular symmetry extends to sp3-hybridized nitrogen, phosphorus and sulfur centers, including trivalent molecules with lone pairs. Here, the lone pair behaves as a functional group in addition to the other three substituents to form an analogous tetrahedral center that can be chiral.
A consequence of chirality is the need for enantiomeric resolution. While this is theoretically possible for all...

Stereoisomerism

Stereoisomerism

Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...

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Related Experiment Video

Updated: Dec 29, 2025

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates

Published on: February 15, 2016

Supramolecular Chiral 2D Materials and Emerging Functions.

Bowen Shen¹, Yongju Kim², Myongsoo Lee^1,3

¹State Key Lab of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, 130012, China.

Advanced Materials (Deerfield Beach, Fla.)

|February 4, 2020

Summary

Researchers are developing novel 2D chiral materials using supramolecular chemistry for advanced applications. These materials offer unique properties and high surface areas, overcoming challenges in creating functional chiral architectures.

Keywords:

2D chiral materials 2D porous materials supramolecular materials

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Assembly of Gold Nanorods into Chiral Plasmonic Metamolecules Using DNA Origami Templates

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Last Updated: Dec 29, 2025

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates

Published on: February 15, 2016

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs

Published on: January 17, 2020

Assembly of Gold Nanorods into Chiral Plasmonic Metamolecules Using DNA Origami Templates

Assembly of Gold Nanorods into Chiral Plasmonic Metamolecules Using DNA Origami Templates

Published on: March 5, 2019

Area of Science:

Materials Science
Supramolecular Chemistry
Chirality

Background:

Chiral materials are crucial for stereospecific applications like enantiomeric separation and asymmetric catalysis.
Supramolecular chemistry enables the design of chiral materials with unique properties via well-defined scaffolds.
Two-dimensional (2D) chiral sheet structures offer high surface area and potential for advanced optically active systems and optoelectronics.

Purpose of the Study:

To provide an overview of recent advances in constructing chiral supramolecular 2D materials.
To discuss design principles for achieving 2D chirality.
To explore potential applications of these novel materials.

Main Methods:

Review of recent literature on the synthesis and characterization of 2D chiral materials.
Analysis of supramolecular strategies for incorporating chirality into 2D architectures.
Discussion of structure-property relationships and functionalization.

Main Results:

Limited examples of functional 2D chiral materials exist due to challenges in incorporating molecular chirality into 2D frameworks.
Supramolecular approaches offer promising routes to overcome these limitations.
Recent advances highlight progress in designing and fabricating these complex structures.

Conclusions:

2D chiral materials hold significant promise for next-generation functional materials, particularly in optics and electronics.
Further research into design principles and construction methods is essential for realizing their full potential.
Overcoming fabrication challenges is key to expanding the applications of these advanced materials.