Related Experiment Video
Updated: Dec 29, 2025
07:03
Isolation, Characterization, and Therapeutic Application of Extracellular Vesicles from Cultured Human Mesenchymal Stem Cells
Published on: September 23, 2022
2.5K
Mesenchymal Stem Cell-Derived Extracellular Vesicles: A Novel Cell-Free Therapy
Morteza Jafarinia1, Fereshteh Alsahebfosoul1, Hossein Salehi2
1Department of Immunology, School of Medicine, Isfahan University of Medical Sciences , Isfahan, Iran.
Immunological Investigations
|February 4, 2020
Summary
Mesenchymal stem/stromal cell-derived extracellular vesicles (MSC-EVs) offer therapeutic advantages over cells. These MSC-EVs show promise for treating various diseases, including inflammatory conditions, in preclinical models.
Area of Science:
- Biomedical Science
- Regenerative Medicine
- Cell Biology
Background:
- Mesenchymal stem/stromal cells (MSCs) are investigated for therapeutic potential.
- MSCs exert therapeutic effects primarily through paracrine signaling, including trophic factors and extracellular vesicles (EVs).
- EVs offer advantages over cells as therapeutic agents, lacking self-replication and associated risks like tumor formation or immune rejection.
Purpose of the Study:
- To review the properties and applications of MSC-derived EVs (MSC-EVs).
- To highlight MSC-EVs as a promising therapeutic approach for various diseases, particularly inflammatory conditions.
Main Methods:
- Literature review of studies on MSC-EVs.
- Analysis of MSC-EV properties and therapeutic effects in preclinical disease models.
Main Results:
- MSC-EVs mimic the therapeutic effects of parent MSCs.
- MSC-EVs demonstrate efficacy in animal models of kidney, liver, cardiovascular, immunological, and neurological diseases.
- MSC-EVs possess inherent properties like homing to injury sites and immunomodulatory capabilities.
Conclusions:
- MSC-EVs represent a novel and advantageous therapeutic strategy.
- Further investigation of MSC-EVs in clinical trials for inflammatory diseases is warranted.
Related Concept Videos
01:19Mesenchymal Stem Cells
5.4K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
5.4K
01:36Overview of Exosomes
3.4K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
3.4K