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MicroRNAs01:22

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research
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Environmental Influencers, MicroRNA, and Multiple Sclerosis.

Eiman Ma Mohammed1

  • 1Kuwait Cancer Control Center, Ministry of Health, Shuwaikh, Kuwait.

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|February 4, 2020
PubMed
Summary
This summary is machine-generated.

Environmental factors like vitamin D deficiency, Epstein-Barr virus (EBV), and smoking may trigger multiple sclerosis (MS) by disrupting microRNA (miRNA) networks. This disruption impacts cellular processes, potentially leading to MS development.

Keywords:
EBVEpstein-Barr virusMSMS aetiologyMS pathogenesisMultiple sclerosiscigarette smokingmiRNAmicroRNAvitamin D

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Area of Science:

  • Neuroimmunology
  • Molecular Biology
  • Genetics

Background:

  • Multiple sclerosis (MS) is a debilitating neurological disorder with an autoimmune component.
  • Environmental factors such as vitamin D deficiency, Epstein-Barr virus (EBV) infection, and smoking are implicated in MS.
  • These factors may alter cellular functions including proliferation, differentiation, and apoptosis.

Purpose of the Study:

  • To review the potential role of environmental factors in multiple sclerosis (MS) pathogenesis.
  • To explore the influence of microRNAs (miRNAs) in mediating the effects of these environmental factors.
  • To propose a theoretical model linking environmental factors, miRNA dysregulation, and MS.

Main Methods:

  • Literature review of existing studies on MS, environmental factors, and miRNAs.
  • Analysis of proposed mechanisms by which environmental factors affect cellular processes.
  • Synthesis of evidence to support the hypothesis of miRNA involvement in MS.

Main Results:

  • Environmental factors can influence cellular molecularity and function.
  • MicroRNAs (miRNAs) are key regulators of cellular processes potentially affected by these factors.
  • Dysregulation of the miRNA network is hypothesized to contribute to MS pathogenicity.

Conclusions:

  • Environmental factors may induce MS by disrupting the miRNA network.
  • MicroRNA dysregulation represents a potential mechanism linking environmental exposures to MS.
  • Further research into miRNA-environment interactions is warranted for understanding MS etiology.