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Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

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Related Experiment Video

Updated: Jun 23, 2026

Identification of Circular RNAs using RNA Sequencing
08:25

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Circular RNA in Multiple Sclerosis: Pathogenicity and Potential Biomarker Development: A Systematic Review.

Eiman M Mohammed1

  • 1Kuwait Cancer Control Centre, Medical Laboratory Department, Molecular Genetics Laboratory, Ministry of Health, Shuwaikh, Kuwait.

Epigenetics Insights
|November 30, 2023
PubMed
Summary
This summary is machine-generated.

Circular RNAs (circRNAs) show altered expression in multiple sclerosis (MS) patients, potentially indicating disease involvement. These RNA molecules may serve as novel biomarkers for MS pathology.

Keywords:
CircRNAMultiple sclerosisautoimmune diseasecircular RNAdemyelinating diseasemultiple sclerosis biomarkersneurodegenerative diseasenon-coding RNA

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Area of Science:

  • Neuroimmunology
  • Molecular Biology
  • Genetics

Background:

  • Multiple Sclerosis (MS) is a debilitating autoimmune disease of the central nervous system (CNS) with unknown etiology, affecting millions globally.
  • Circular RNAs (circRNAs) are stable, non-coding RNA molecules with specific expression patterns, recognized for their potential as disease biomarkers.

Purpose of the Study:

  • To review the role of circRNAs in the pathogenicity of Multiple Sclerosis (MS).
  • To evaluate the potential of circRNAs as diagnostic or prognostic biomarkers for MS.

Main Methods:

  • A comprehensive literature search was conducted across eight scientific databases.
  • Analysis focused on studies reporting circRNA expression differences in MS patients versus healthy controls (HC).
  • Investigated the association between MS-associated single nucleotide polymorphisms (SNPs) and circRNA expression within linkage disequilibrium (LD) blocks.

Main Results:

  • Differential expression of circRNAs was observed in MS patients compared to HC.
  • Expression differences were more pronounced across various MS subtypes.
  • Enrichment of circRNAs within LD blocks containing MS-associated SNPs suggests a regulatory role in disease pathogenesis.

Conclusions:

  • CircRNAs are implicated in the pathogenicity of Multiple Sclerosis.
  • CircRNAs demonstrate significant potential as biomarkers for MS disease pathology.
  • Further research is warranted to elucidate the full biological impact and clinical utility of circRNAs in MS.