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VARIATIONS OF ADIPOKINE PROFILE IN PATIENTS DIAGNOSED WITH RECTAL CARCINOMA
A Florescu1, S Bilha1, I Grigoras2
1"Gr. T. Popa" University of Medicine and Pharmacy -, Endocrinology, Iasi, Romania.
Acta Endocrinologica (Bucharest, Romania : 2005)
|February 4, 2020
Summary
Rectal carcinoma (RC) alters adipokine profiles, with leptin and adiponectin levels differing significantly between patients and healthy individuals. These changes may aid in predicting disease progression.
Area of Science:
- Endocrinology
- Oncology
- Metabolic Research
Background:
- Adipokine secretion is significantly impacted by various pathological conditions.
- Understanding these alterations is crucial for disease management and prognosis.
Purpose of the Study:
- To investigate the specific impact of rectal carcinoma (RC) on the circulating adipokine profile.
- To compare adipokine levels in RC patients with those of healthy controls.
Main Methods:
- Serum leptin and adiponectin levels were measured in 24 RC patients and 24 matched healthy controls.
- Patients and controls were matched for age, sex, and body weight.
Main Results:
- Adipokine levels showed inverse correlations with body weight in both controls and RC patients.
- Women exhibited higher adipokine levels than men across both groups.
- Healthy controls had significantly higher leptin and lower adiponectin levels compared to RC patients (p<0.05).
Conclusions:
- Adipokine profiles in rectal carcinoma patients are distinct from those in the healthy population.
- Observed differences may represent an adaptive response to RC rather than a causative factor.
- These adipokine alterations hold potential for clinical application in predicting disease progression.
