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Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold
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Shape-morphing living composites.

L K Rivera-Tarazona1, V D Bhat2, H Kim1

  • 1Department of Bioengineering, The University of Texas at Dallas, Richardson, TX, USA.

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|February 4, 2020
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Summary
This summary is machine-generated.

Researchers created living synthetic composites using engineered yeast that change shape in response to specific stimuli. These responsive materials, capable of significant volume changes, could lead to advanced biosensors and medical devices.

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Area of Science:

  • Synthetic Biology
  • Biomaterials Engineering
  • Cellular Engineering

Background:

  • Living materials offer unique responsive properties not achievable with inert substances.
  • Genetic networks can be harnessed to control cellular behavior and material characteristics.
  • Hydrogel encapsulation provides a scaffold for cellular growth and material integration.

Purpose of the Study:

  • To develop living synthetic composites with controllable shape-changing capabilities.
  • To engineer yeast for specific responses to biochemical and physical cues.
  • To explore applications in responsive sensors and medical devices.

Main Methods:

  • Embedding genetically modified Baker's yeast within a hydrogel matrix.
  • Utilizing cellular proliferation to induce controllable volume changes in the composite material.
  • Implementing genetic engineering to achieve stimulus-specific responses (e.g., to l-histidine).
  • Incorporating an optogenetic switch for light-induced, spatiotemporal control of shape change.

Main Results:

  • Achieved controllable composite volume increases of up to 400% through yeast proliferation.
  • Demonstrated a 14-fold greater volume change in response to l-histidine compared to d-histidine or other amino acids.
  • Successfully induced spatiotemporally controlled shape changes using blue light pulses via an optogenetic switch.

Conclusions:

  • Living synthetic composites can be created by exploiting genetic networks in yeast.
  • These materials exhibit precise, stimulus-responsive shape and volume changes.
  • Potential applications include advanced biosensors and medical devices responding to specific biological cues.