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Disorders of Leukocytes

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Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia

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Published on: October 17, 2025

Neonatal Acute Lymphoblastic Leukemia.

Rachel Oliver¹, Andrew L Juergens², Derek Hatch³

¹From the Texas A&M Health Science Center, Bryan.

Pediatric Emergency Care

|February 4, 2020

Summary

This summary is machine-generated.

Neonatal acute lymphoblastic leukemia (ALL) presents like other infant illnesses. This case highlights a rare diagnosis in a 24-hour-old infant, leading to palliative care due to high mortality risks.

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Area of Science:

Pediatric Oncology
Neonatal Hematology
Cancer Genetics

Background:

Neonatal acute lymphoblastic leukemia (ALL) is rare but presents with non-specific symptoms, mimicking other serious infant conditions.
Early recognition is crucial for appropriate management and improved outcomes in neonates.

Observation:

A 24-hour-old male infant presented with a rash and decreased movement.
Initial laboratory findings included a markedly elevated white blood cell count (822 × 10^9 cells/L).
Genetic analysis revealed a complex t(9;19;11) translocation, confirming neonatal ALL.

Findings:

The infant was diagnosed with a rare and aggressive form of acute lymphoblastic leukemia presenting at birth.
The complex chromosomal translocation t(9;19;11) is a key diagnostic indicator for this specific subtype of neonatal ALL.

Implications:

The high morbidity and mortality associated with neonatal ALL influenced the parents' decision.
The case underscores the importance of considering rare hematologic malignancies in critically ill neonates.
Focus shifted to palliative and symptomatic care due to the grim prognosis and treatment burdens.