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The Significant Association of MMP-1 Genotypes With Taiwan Pterygium
Chong-Bin Tsai1, Ning-Yi Hsia2,3, Yun-Chi Wang3
1Department of Ophthalmology, Ditmanson Medical Foundation, Chia-Yi Christian Hospital, Chia-Yi, Taiwan, R.O.C.
Background/Aim:
Few studies have examined the contribution of matrix metalloproteinases (MMP) to either diagnosis or prognosis of pterygium. The aim of this study was to investigate the contribution of MMP-1 genotypes to pterygium risk.
Patients And Methods:
A total of 134 cases and 268 controls were included and their MMP-1 -1607 (rs1799705) genotypes were examined by polymerase chain reaction-restriction fragment length polymorphism.
Results:
The percentages of 2G/2G, 1G/2G, and 1G/1G for rs1799705 genotypes were 48.5, 36.6 and 14.9% among patients and 33.9, 44.8, and 21.3% among controls (p trend=0.0167). The odds ratios (ORs) after adjusting for age and gender for 1G/2G and 1G/1G genotypes at rs1799705 were 0.54 (95%CI=0.33-0.89, p=0.0168) and 0.46 (95%CI=0.27-0.88, p=0.0192), respectively. Consistently, the adjusted OR for those carrying the 1G allele at MMP-1 -1607 was 0.61 (95%CI=0.41-0.78, p=0.0167), compared with the wild-type 2G allele.
Conclusion:
The genotypes at rs1799705 play a role in determining personal susceptibility to pterygium.
Insights
Matrix metalloproteinase-1 (MMP-1) gene variations influence pterygium risk. Specific MMP-1 genotypes, particularly the 1G allele, are associated with a reduced risk of developing this eye condition.
Area of Science:
- Ophthalmology
- Genetics
- Molecular Biology
Background:
- Pterygium is a common eye condition with limited understanding of its genetic underpinnings.
- Matrix metalloproteinases (MMPs) are implicated in tissue remodeling, but their role in pterygium is not well-defined.
Purpose of the Study:
- To investigate the association between matrix metalloproteinase-1 (MMP-1) gene polymorphisms and the risk of developing pterygium.
- To determine if specific MMP-1 genotypes contribute to pterygium susceptibility.
Main Methods:
- A case-control study involving 134 pterygium cases and 268 controls.
- Genotyping of the MMP-1 -1607 (rs1799705) polymorphism using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
Main Results:
- Significant differences in genotype frequencies were observed between cases and controls (p trend=0.0167).
- Carrying the 1G/2G or 1G/1G genotypes at rs1799705 was associated with a reduced odds of pterygium (OR=0.54 and OR=0.46, respectively).
- The presence of the 1G allele at MMP-1 -1607 significantly decreased pterygium risk (adjusted OR=0.61).
Conclusions:
- The study demonstrates that MMP-1 gene polymorphisms, specifically at the -1607 locus, play a role in determining an individual's susceptibility to pterygium.
- These genetic variations may influence the risk of developing pterygium, suggesting a potential genetic predisposition.
