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Published on: February 5, 2020
Efficacy of PD-1 Inhibitors in Older Non-small Cell Lung Cancer Patients
Yukiko Nakamura1, Kazuhito Miyazaki2, Naoto Aiko2
1Department of Respiratory Medicine, Yokohama Municipal Citizen's Hospital, Yokohama, Japan y-tanji@fc4.so-net.ne.jp.
Background/Aim:
We assessed the efficacy of immune checkpoint inhibitors (ICIs) in older patients because of the limited information regarding these patients.
Patients And Methods:
We retrospectively analyzed 66 consecutive patients ≥70 years old with advanced non-small cell lung cancer (NSCLC). A total of 31 patients received ICIs (ICIs group) and 35 patients received only cytotoxic regimens (No ICIs group).
Results:
Patients with squamous cell carcinoma who received ICIs had better overall survival (OS) than those who did not (9.7 versus 4.7 months, p=0.027). In multivariate analysis, treatment with ICIs [hazard ratio (HR)=0.54, 95% confidence interval (CI)=0.30-0.98, p=0.044], good performance status (HR=0.30, 95%CI=0.16-0.57, p=0.0003), and histology other than squamous cell carcinoma (HR=0.41, 95%CI=0.19-0.83, p=0.014) were significantly favorable factors for OS.
Conclusion:
ICIs may be effective for older patients with NSCLC, especially squamous cell carcinoma patients.
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