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Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA
Published on: December 19, 2019
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Can atopy have a protective effect against cancer?
Andrzej Bożek1, Jerzy Jarzab1, Michal Mielnik2
1Clinical Department of Internal Disease, Dermatology and Allergology in Zabrze, Medical University of Silesia, Katowice, Poland.
Plos One
|February 5, 2020
Summary
This study found that allergies, particularly allergic rhinitis, are less common in women with breast cancer. This suggests a potential protective effect of atopy against breast cancer risk.
Area of Science:
- Immunology
- Oncology
- Epidemiology
Background:
- Rising prevalence of allergies and breast cancer incidence noted.
- Investigated the hypothesis of atopy (allergic predisposition) as a protective factor against breast cancer risk.
Purpose of the Study:
- To evaluate the potential protective effect of atopy against different types of breast cancer.
- To assess the association between allergic diseases and breast cancer incidence.
Main Methods:
- Retrospective analysis of 11,101 breast cancer patients and a control group.
- Confirmed allergies via diagnostic procedures and assessed prevalence of allergic rhinitis, asthma, and atopic dermatitis.
- Measured mean serum concentrations of total IgE.
Main Results:
- Significantly lower incidence of IgE-mediated allergic diseases in breast cancer patients compared to controls.
- Odds ratios for allergic rhinitis, atopic dermatitis, and asthma were notably reduced (0.61, 0.17, 0.73 respectively).
- Lower mean serum total IgE levels observed in breast cancer patients.
Conclusions:
- Incidence of allergies, especially allergic rhinitis, is lower in breast cancer patients.
- Findings suggest a potential inverse relationship between atopy and breast cancer.
- Further research is required to confirm these observations.
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