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The role of oligopeptides in preventing autism

Gary Steinman1, David Mankuta1

  • 1Dept. of Obstetrics & Gynecology, Hadassah Hospital - Hebrew University, Ein Kerem, Jerusalem 12000, Israel.

Medical Hypotheses
|February 5, 2020
PubMed

Insights

Low insulin-like growth factor-1 (IGF1) in newborns may cause autism-related brain dysconnectivity. Early detection via blood tests and interventions like breastfeeding or oral supplements could be beneficial.

Area of Science:

  • Neurodevelopmental disorders
  • Endocrinology

Background:

  • Autism Spectrum Disorder (ASD) is increasingly linked to brain dysconnectivity.
  • Previous research suggests a potential role for insulin-like growth factor-1 (IGF1) deficiency in this process.

Purpose of the Study:

  • To investigate the hypothesis that insufficient newborn insulin-like growth factor-1 (IGF1) is a key factor in autism-related brain dysconnectivity.
  • To explore potential early detection and intervention strategies.

Main Methods:

  • Analysis of serum insulin-like growth factor-1 (IGF1) levels in newborns.
  • Review of potential interventions to increase IGF1 levels.

Main Results:

  • Insufficient serum IGF1 in newborns is proposed as a critical indicator for autism-related brain dysconnectivity.
  • Early detection of IGF1 deficiency is feasible through blood analysis shortly after birth.

Conclusions:

  • Low IGF1 levels at birth may be a significant biomarker for autism risk.
  • Exclusive breastfeeding for one year or oral supplementation (e.g., cyclo-glycylproline) may help normalize IGF1 levels and support neurodevelopment.

Keywords:
AutismBreast-feedingDysconnectivityIGF1MyelinationPolymorphismcGP

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