The ageing epigenome and its rejuvenation

Area of Science:

• Gerontology and Epigenetics: Focuses on the biological processes of ageing and the molecular mechanisms of gene regulation.

Background:

• Ageing involves functional decline and increased disease risk.
• Epigenetic alterations (DNA methylation, histone modification, non-coding RNAs) are hallmarks of ageing.
• Current interventions aim to delay ageing and extend healthspan and lifespan.

Purpose of the Study:

• To review epigenetic changes during ageing.
• To discuss how epigenetic mechanisms influence healthspan and lifespan.
• To identify future research directions for epigenetic rejuvenation.

Main Methods:

• Literature review of epigenetic mechanisms in ageing.
• Analysis of interventions targeting epigenetic modifications.
• Discussion of current knowledge and future research needs.

Main Results:

• Epigenetic alterations are central to the ageing process.
• Manipulation of epigenetic mechanisms is key to effective age-delaying interventions.
• Significant progress has been made in understanding epigenetics and ageing.

Conclusions:

• Epigenetic rejuvenation holds promise for delaying ageing.
• Targeting the epigenome can extend healthspan and lifespan.
• Further research is needed to optimize epigenetic interventions for ageing.