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Updated: Dec 29, 2025
07:26
Site Specific Lysine Acetylation of Histones for Nucleosome Reconstitution using Genetic Code Expansion in Escherichia coli
Published on: December 26, 2020
4.3K
Revealing eukaryotic histone-modifying mechanisms through bacterial infection
Wenyang Dong1,2, Melanie Anne Hamon3
1G5 Chromatine et Infection, Institut Pasteur, 75015, Paris, France.
Seminars in Immunopathology
|February 6, 2020
Summary
Bacteria manipulate host transcription by altering histone modifications. This review explores bacterial strategies for inducing histone post-translational modifications (PTMs) and their impact on host cell biology.
Area of Science:
- Microbiology
- Molecular Biology
- Epigenetics
Background:
- Host-pathogen interactions involve bacterial manipulation of host cell transcription.
- Histone post-translational modifications (PTMs) are key regulators of gene expression and are targeted during infection.
Purpose of the Study:
- To review bacterial mechanisms for inducing histone PTMs.
- To summarize cell biology insights gained from studying bacteria-induced histone modifications.
Main Methods:
- Focus on bacteria-induced histone modifications.
- Discussion of direct targeting of pathogen effector enzymes.
- Analysis of indirect modulation of cellular signaling cascades.
Main Results:
- Bacteria employ diverse strategies to induce histone PTMs.
- Bacterial effectors directly target histones or modulate signaling pathways.
- Novel histone marks are imposed upon infection, revealing host cell regulatory mechanisms.
Conclusions:
- Studying bacteria-induced histone modifications enhances understanding of virulence and host cell biology.
- Bacterial manipulation of chromatin offers insights into signaling cascades and enzyme mimicry.
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