Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multiple sclerosis: the lipid relationship.

R L Swank1, A Grimsgaard

  • 1Department of Neurology, Oregon Health Sciences University, Portland 97201.

The American Journal of Clinical Nutrition
|December 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Combat neuroses; development of combat exhaustion.

Archives of neurology and psychiatry·2010
Same author

AVIAN THIAMIN DEFICIENCY : A CORRELATION OF THE PATHOLOGY AND CLINICAL BEHAVIOR.

The Journal of experimental medicine·2009
Same author

How saturated fats may be a causative factor in multiple sclerosis and other diseases.

Nutrition (Burbank, Los Angeles County, Calif.)·2003
Same author

Microfiltration and microemboli: a history.

Transfusion·2000
Same author

A prospective discussion of past international nutrition catastrophes--indications for the future.

Nutrition (Burbank, Los Angeles County, Calif.)·1997
Same author

Pyloric stenosis.

Pediatric annals·1994
Same journal

High postprandial endotoxemia is associated with recurrence of cardiovascular events in patients with coronary heart disease: from the CORDIOPREV randomized clinical trial.

The American journal of clinical nutrition·2026
Same journal

Reply to Wu et al.: "Nitrate and nitrite food composition database: an update and extensive deep dive".

The American journal of clinical nutrition·2026
Same journal

Reframing Basic Experimental Studies in Humans-Implications for Nutrition Science.

The American journal of clinical nutrition·2026
Same journal

Inconvenient for the investigator but convenient for science: trial registration in The American Journal of Clinical Nutrition.

The American journal of clinical nutrition·2026
Same journal

Energy requirements revisited: why the factorial model still matters.

The American journal of clinical nutrition·2026
Same journal

Letter to the Editor: Temporal eating pattern classification should be separated from model attribution and reporting artifacts.

The American journal of clinical nutrition·2026
See all related articles

Multiple sclerosis patients on low-fat diets showed less disability and fewer deaths. Higher fat intake correlated with severe disability and increased mortality, suggesting fats may be involved in multiple sclerosis.

Area of Science:

  • Neurology
  • Nutritional Science

Background:

  • Multiple sclerosis (MS) is a chronic neurological disease.
  • Dietary factors are increasingly investigated for their role in MS.
  • Long-term studies on specific dietary interventions in MS are limited.

Purpose of the Study:

  • To investigate the long-term effects of low-fat diets on multiple sclerosis patients.
  • To determine the relationship between fat and oil intake and disease progression, disability, and mortality in MS.

Main Methods:

  • A cohort of 150 multiple sclerosis patients was observed between 1949 and 1984.
  • Dietary intake, particularly of fats and oils, was recorded.
  • Patient disability levels and mortality data were systematically collected.

Related Experiment Videos

Main Results:

  • Patients consuming less than 20.1 g of fat daily (average 17 g) experienced slight deterioration, with a 31% mortality rate.
  • Patients consuming over 20 g of fat daily (average 25 g or 41 g) exhibited severe disability and significantly higher mortality rates (79% and 81%).
  • Early treatment and intervention before severe disability onset improved patient prognosis, with females generally faring better than males.

Conclusions:

  • High fat consumption appears to be associated with severe disability and increased mortality in multiple sclerosis patients.
  • Dietary fat intake may play a role in the pathogenesis of multiple sclerosis.
  • Timely intervention and dietary modification, particularly fat reduction, could be beneficial for managing MS.