Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Complement deficiency. Predisposing factor to autoimmune syndromes.

J P Atkinson1

  • 1Howard Hughes Medical Institute Laboratories, Washington University School of Medicine, St. Louis, Missouri.

The American Journal of Medicine
|December 23, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The rare C9 P167S risk variant for age-related macular degeneration increases polymerization of the terminal component of the complement cascade.

Human molecular genetics·2021
Same author

Dysfunction of complement receptors CR3 (CD11b/18) and CR4 (CD11c/18) in pre-eclampsia: a genetic and functional study.

BJOG : an international journal of obstetrics and gynaecology·2021
Same author

Complement regulators in human disease: lessons from modern genetics.

Journal of internal medicine·2014
Same author

Complement receptor structure and function.

Immunology today·2014
Same author

The 20 faces of the fourth component of complement.

Immunology today·2014
Same author

Human C3b- and C4b-regulatory proteins: a new multi-gene family.

Immunology today·2014
Same journal

GLP-1 Receptor Agonists and Age-related Macular Degeneration Risk in Diabetes or Non-diabetic Obesity: A Retrospective Cohort Study.

The American journal of medicine·2026
Same journal

Marijuana Use and Acute Myocardial Infarction: Mechanistic Insights, Clinical Implications, and Emerging Challenges.

The American journal of medicine·2026
Same journal

Cave Canem - Beware of the Dog.

The American journal of medicine·2026
Same journal

Risk Factors for 30-day Hospital Readmission After Hospital-at-Home Treatment of Acute Pyelonephritis.

The American journal of medicine·2026
Same journal

Mesenteric Panniculitis.

The American journal of medicine·2026
Same journal

Hypercalcemia and hyperferritinemia in a patient with Graves' disease disease.

The American journal of medicine·2026
See all related articles

Complement deficiencies are linked to immune complex diseases like lupus. Understanding complement

Area of Science:

  • Immunology
  • Pathophysiology

Background:

  • Complete and partial complement (C) deficiencies are associated with immune complex-mediated diseases.
  • Deficiencies in early complement components (C1, C4, C2, C3) impair immune complex solubility and clearance.
  • Systemic lupus erythematosus (SLE) is characterized by excessive, deposited immune complexes.

Purpose of the Study:

  • To investigate the clinical and etiopathologic significance of complement deficiencies in immune complex diseases.
  • To elucidate the role of complement in immune complex processing and its relation to disease development.
  • To explore complement deficiencies as predisposing factors for autoimmune diseases.

Main Methods:

  • Studies of sera deficient in C1, C4, C2, or C3.
  • Analysis of the prevalence of C4 deficiencies in patients with systemic lupus erythematosus.

Related Experiment Videos

  • Pathophysiological examination of the relationship between complement function and immune complex syndromes.

    • Main Results:

    • Early complement components are crucial for immune complex solubility and clearance.
    • Partial C4 deficiency is a significant risk factor for systemic lupus erythematosus.
    • Complete C4A deficiency (C4A null) affects 10-15% of SLE patients, and heterozygous deficiency affects 50-80%.

    Conclusions:

    • Complement deficiencies play a critical role in the pathogenesis of immune complex-mediated diseases.
    • Understanding complement's role in immune complex processing offers insights into autoimmune disease origins.
    • Subtle complement component and receptor deficiencies may predispose individuals to autoimmune conditions.