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Anorexia, Hypertension, Pneumothorax, and Hypothyroidism: Potential Signs of Improved Clinical Outcome Following

Lu Xie1, Jie Xu1, Xin Sun1

  • 1Musculoskeletal Tumor Center, Peking University People's Hospital, Beijing, People's Republic of China.

Cancer Management and Research
|February 6, 2020
PubMed
Abstract

Insights

Apatinib treatment for advanced osteosarcoma showed that certain adverse events like anorexia and hypertension may indicate a better clinical outcome. These findings help predict treatment response in refractory osteosarcoma patients.

Area of Science:

  • Oncology
  • Pharmacology
  • Clinical Trials

Background:

  • Apatinib is a tyrosine kinase inhibitor (TKI) targeting VEGFR-2, Ret, c-Kit, and c-Src.
  • Previous studies have assessed apatinib in advanced osteosarcoma, with this sub-study focusing on adverse events.

Purpose of the Study:

  • To explore potential adverse event (AE) markers associated with favorable clinical outcomes in patients with advanced osteosarcoma treated with apatinib.
  • To evaluate the safety and efficacy of apatinib in refractory osteosarcoma.

Main Methods:

  • A phase II sub-study involving patients with advanced osteosarcoma progressing on chemotherapy.
  • Patients received apatinib until disease progression or unacceptable toxicity, with toxicities, progression-free survival (PFS), and clinical benefit rate (CBR) evaluated.

Main Results:

  • The most common grade 3-4 adverse events included pneumothorax (16.22%), wound dehiscence (10.81%), proteinuria (8.11%), diarrhea (8.11%), and skin reaction (8.11%).
  • Hypertension was an independent predictive factor for both PFS and CBR.
  • Anorexia was significantly related to longer PFS, and pneumothorax and hypothyroidism were associated with greater clinical benefit for CBR.

Conclusions:

  • Anorexia, hypertension, pneumothorax, and hypothyroidism may serve as predictive markers for favorable clinical outcomes in apatinib-treated refractory osteosarcoma.
  • These findings can aid in predicting treatment response and managing patients with advanced osteosarcoma.
Keywords:
apatinibosteosarcomaprognosis

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