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[A review of immune-related adverse events associated with immunotherapy]

Y Fang1, Y Yu, D W Wu

  • 1GCP center, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

Zhonghua Zhong Liu Za Zhi [Chinese Journal of Oncology]
|February 7, 2020
PubMed

Immune checkpoint inhibitors have been approved for clinical application in China. However, the increased immune-related adverse event (irAE) needs more attention. This review summarized the incidence, characteristic clinical manifestation and treatment of irAEs associated with programmed cell death protein-1(PD-1) and programmed cell death ligand-1(PD-L1) inhibitors. To have a deep insight into irAE, the potential mechanisms, the different incidences of cancer types, influencing factors and the direction of future research were also discussed here to provide guidance for clinical oncologist to identify and monitor irAE.

Keywords:
Immune checkpoint inhibitorImmune related adverse eventsPD-1 inhibitorPD-L1 inhibitor

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