Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Revascularization of Transcortical Vessels Improves Tendon-to-Bone Healing for Rotator Cuff Repair.

The American journal of sports medicine·2026
Same author

Multi-omics analysis of changes in the microbiota-gut- spinal cord axis in spinal cord injury.

Neural regeneration research·2026
Same author

National trends and disparities in non-cancer mortality among older adults with oral cancer in the United States, 1999-2020.

Frontiers in oncology·2026
Same author

An integrated analysis of spinal cord transcriptome and gut microbiome unravel age-associated host-microbiome interactions following spinal cord injury.

Frontiers in immunology·2026
Same author

TIR domain-containing proteins employ dual regulatory mechanisms to confer TaEDS1-dependent immunity in wheat.

Molecular plant·2026
Same author

Forensic investigative genetic genealogy based on low-quality DNA whole genome sequencing data.

Forensic science international. Genetics·2025

Related Experiment Video

Updated: Dec 29, 2025

X-ray Dose Reduction through Adaptive Exposure in Fluoroscopic Imaging
08:30

X-ray Dose Reduction through Adaptive Exposure in Fluoroscopic Imaging

Published on: September 11, 2011

14.8K

Low-dose photon counting CT reconstruction bias reduction with multi-energy alternating minimization algorithm.

Jingwei Lu1, Shuangyue Zhang1, David G Politte2

  • 1Washington University in St. Louis, Department of Electrical and Systems Engineering, 1 Brookings Dr, St. Louis, MO 63130 USA.

Proceedings of Spie--The International Society for Optical Engineering
|February 7, 2020
PubMed
Summary

Photon counting CT (PCCT) offers improved imaging at lower doses. A new algorithm, MEAM-PCCT, directly reconstructs material-decomposed images, outperforming traditional methods in low-dose situations.

Keywords:
alternating minimizationiterative algorithmlow-dose radiationphoton countingspectral x-ray CT

More Related Videos

Author Spotlight: Enhanced Quantification of Cardiovascular Calcification Progression for Longitudinal Micro PET/CT Studies in Small Research Animals
08:02

Author Spotlight: Enhanced Quantification of Cardiovascular Calcification Progression for Longitudinal Micro PET/CT Studies in Small Research Animals

Published on: November 15, 2024

901
Management of Respiratory Motion Artefacts in 18F-fluorodeoxyglucose Positron Emission Tomography using an Amplitude-Based Optimal Respiratory Gating Algorithm
06:53

Management of Respiratory Motion Artefacts in 18F-fluorodeoxyglucose Positron Emission Tomography using an Amplitude-Based Optimal Respiratory Gating Algorithm

Published on: July 23, 2020

6.0K

Related Experiment Videos

Last Updated: Dec 29, 2025

X-ray Dose Reduction through Adaptive Exposure in Fluoroscopic Imaging
08:30

X-ray Dose Reduction through Adaptive Exposure in Fluoroscopic Imaging

Published on: September 11, 2011

14.8K
Author Spotlight: Enhanced Quantification of Cardiovascular Calcification Progression for Longitudinal Micro PET/CT Studies in Small Research Animals
08:02

Author Spotlight: Enhanced Quantification of Cardiovascular Calcification Progression for Longitudinal Micro PET/CT Studies in Small Research Animals

Published on: November 15, 2024

901
Management of Respiratory Motion Artefacts in 18F-fluorodeoxyglucose Positron Emission Tomography using an Amplitude-Based Optimal Respiratory Gating Algorithm
06:53

Management of Respiratory Motion Artefacts in 18F-fluorodeoxyglucose Positron Emission Tomography using an Amplitude-Based Optimal Respiratory Gating Algorithm

Published on: July 23, 2020

6.0K

Area of Science:

  • Medical Imaging
  • Radiology
  • Computational Imaging

Background:

  • Photon counting CT (PCCT) is an advanced x-ray imaging modality with significant recent development.
  • PCCT demonstrates potential for enhanced dose efficiency and improved performance at low radiation doses.
  • Accurate material decomposition is crucial for quantitative analysis in CT imaging.

Purpose of the Study:

  • To propose a novel statistics-based iterative algorithm for direct reconstruction of material-decomposed images in PCCT.
  • To evaluate the performance of the proposed algorithm, termed multi-energy alternating minimization algorithm for photon counting CT (MEAM-PCCT), particularly in low-dose scenarios.
  • To compare MEAM-PCCT against conventional sinogram-based decomposition methods.

Main Methods:

  • Development of a statistics-based iterative algorithm for direct image reconstruction.
  • Implementation of the multi-energy alternating minimization approach tailored for PCCT data.
  • Comparative analysis of MEAM-PCCT with conventional sinogram-based methods under varying dose levels.

Main Results:

  • The proposed MEAM-PCCT algorithm enables direct reconstruction of material-decomposed images.
  • MEAM-PCCT achieves accurate material decomposition with significantly reduced bias compared to conventional methods.
  • The algorithm shows superior performance in low-dose scenarios where traditional methods degrade.

Conclusions:

  • The MEAM-PCCT algorithm provides an effective solution for material decomposition in photon counting CT.
  • This method offers improved accuracy and robustness, especially under low-dose conditions.
  • MEAM-PCCT represents a significant advancement for quantitative imaging with PCCT.