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Updated: Dec 29, 2025

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
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Molecular basis of clonal evolution in multiple myeloma

Yusuke Furukawa1, Jiro Kikuchi2

  • 1Division of Stem Cell Regulation, Center for Molecular Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan. furuyu@jichi.ac.jp.

International Journal of Hematology
|February 7, 2020
PubMed
Summary

Multiple myeloma (MM) treatment resistance stems from complex genomic architecture and clonal evolution. Understanding these patterns, including subclone drug sensitivities, is key to developing more effective therapies.

Keywords:
Bone marrow microenvironmentBranching evolutionClonal dynamicsDrug sensitivityNeutral evolution

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