Evidence- and opinion-based consensus from Delphi round 1 of the Asian aplastic anemia recommendation development

Area of Science:

• Hematology
• Internal Medicine
• Clinical Guidelines

Background:

• International aplastic anemia (AA) guidelines face implementation challenges in Asia.
• Limited access to diagnostics, varied treatments, and healthcare policies hinder AA management.
• Region-specific guidance is crucial for diagnosing and managing AA in Asian populations.

Purpose of the Study:

• To establish expert-derived, consensus-based recommendations for aplastic anemia (AA) in Asia.
• To address the unique diagnostic and management needs of AA patients in the Asian region.
• To provide a framework for consistent and effective AA care across diverse Asian healthcare settings.

Main Methods:

• An Asian Aplastic Anemia Working Group of 10 experts was formed.
• An e-Delphi method with asynchronous voting on 16 thematic statements was employed.
• Consensus was defined as ≥80% agreement among participants.

Main Results:

• Sixteen thematic statements and 54 sub-statements were developed covering AA definition, diagnosis, prognosis, and management.
• Fifteen statements achieved consensus after the first round of voting.
• One statement regarding severe AA management requires further discussion.

Conclusions:

• The e-Delphi method successfully generated the first Asian, expert-derived consensus recommendations for AA.
• These recommendations provide crucial guidance tailored to the Asian context.
• The study highlights a path towards improved AA diagnosis and management in Asia.