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Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses
Published on: November 10, 2023
Emerging 2019 Novel Coronavirus (2019-nCoV) Pneumonia.
Fengxiang Song1, Nannan Shi1, Fei Shan1
1From the Departments of Radiology (F. Song, N.S., F. Shan, Z.Z., J.S., Y.S.) and Infectious Disease (H.L., Y.L.), Shanghai Public Health Clinical Center, No. 2501 Caolang Road, Jinshan District, Shanghai 201508, China; Department of the Principal's Office, Fudan University, Shanghai, China (Z.Z.); Cancer Center, University of Michigan, Ann Arbor, Mich (Y.J.); and Shanghai Key Laboratory of Molecular Imaging, Shanghai, China (Y.S.).
Chest CT scans reveal characteristic ground-glass opacity in patients with 2019 Novel Coronavirus (2019-nCoV) pneumonia. These findings, along with fever, cough, and epidemic exposure, aid in early diagnosis of this emerging viral pneumonia.
Area of Science:
- Radiology
- Infectious Diseases
- Pulmonology
Background:
- The detailed chest CT findings for 2019 Novel Coronavirus (2019-nCoV) pneumonia were previously undescribed.
- Emerging infectious diseases necessitate rapid characterization of clinical and imaging presentations.
Purpose of the Study:
- To investigate the clinical, laboratory, and imaging findings of emerging 2019-nCoV pneumonia in humans.
- To establish diagnostic criteria for 2019-nCoV pneumonia based on CT imaging.
Main Methods:
- Retrospective analysis of thin-section CT scans from 51 laboratory-confirmed 2019-nCoV infected patients.
- Evaluation of clinical symptoms, laboratory data, and CT imaging features, including ground-glass opacity (GGO) and consolidation.
- Correlation of CT findings with disease onset, patient age, and follow-up.
Main Results:
- Fever (96%) and cough (47%) were common symptoms; most patients had normal or reduced lymphocyte counts.
- CT scans frequently showed pure GGO (77%) or GGO with thickening (75%), often bilateral (86%), peripheral (86%), and posterior (80%).
- Consolidated lesions increased with disease duration (P < .001) and in patients over 50 years old (P < .001).
Conclusions:
- Patients presenting with fever/cough, peripheral/posterior lung GGO on CT, normal/low white blood cell counts, and epidemic exposure history are highly suspected of 2019-nCoV pneumonia.
- CT imaging plays a crucial role in the early identification and diagnosis of 2019-nCoV pneumonia.
- Understanding CT patterns aids in monitoring disease progression and patient outcomes.
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