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Role of the COP1 protein in cancer development and therapy

Yizuo Song1, Yi Liu1, Shuya Pan1

  • 1Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325027, Zhejiang, China.

Seminars in Cancer Biology
|February 7, 2020
PubMed

Insights

Constitutive photomorphogenesis 1 (COP1), an E3 ubiquitin ligase, regulates cell processes crucial for cancer. COP1

Area of Science:

  • Molecular Biology
  • Oncology
  • Biochemistry

Background:

  • COP1 (Constitutive photomorphogenesis 1) is an E3 ubiquitin ligase involved in regulating cell proliferation, apoptosis, and DNA repair.
  • COP1 targets numerous substrates, including p53, c-Jun, and STAT3, for ubiquitination and degradation, influencing carcinogenesis.
  • COP1 exhibits dual roles, acting as both a tumor suppressor and an oncogene in human malignancies.

Purpose of the Study:

  • To review the structure and known substrates of COP1.
  • To dissect the multifaceted functions of COP1 in tumorigenesis.
  • To evaluate COP1 as a potential therapeutic target for cancer treatment.

Main Methods:

  • Literature review of COP1's role in cancer.
  • Analysis of physiological evidence from mouse models.
  • Examination of pathological evidence from human tumor specimens.
  • Biochemical investigation of COP1's ubiquitin substrates.

Main Results:

  • COP1's structure and a comprehensive list of its substrates are detailed.
  • COP1's dual role in cancer is supported by evidence from various models.
  • COP1's substrates are critical regulators of cell signaling pathways implicated in cancer.

Conclusions:

  • COP1 plays a significant and complex role in human cancer development.
  • Understanding COP1's functions and substrates is crucial for cancer research.
  • COP1 represents a promising therapeutic target for novel cancer therapies.
Keywords:
COP1CarcinogenesisE3 ligaseOncoproteinTherapy

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