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Two mutant low-density-lipoprotein receptors in Afrikaners slowly processed to surface forms exhibiting rapid
A M Fourie1, G A Coetzee, W Gevers
1Department of Medical Biochemistry, University of Cape Town Medical School, South Africa.
The Biochemical Journal
|October 15, 1988
Abstract:
Two distinct mutant low-density-lipoprotein receptors in South African Afrikaners exhibit retarded posttranslational processing to mature forms. One mutation gives rise to cell-surface receptors that are subject to abnormally rapid degradation, whereas the other is associated with a functionally heterogeneous surface population degraded at a normal rate.