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Ionic liquid-supported magnetite nanoparticles as electrode modifier materials for estrogens sensing.

Fernanda Moreira¹, Edson Roberto Santana¹, Almir Spinelli²

¹Grupo de Estudos de Processos Eletroquímicos e Eletroanalíticos, Universidade Federal de Santa Catarina, Campus Universitário Reitor João David Ferreira Lima, Departamento de Química - CFM, 88040-900, Florianópolis, SC, Brazil.

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|February 8, 2020

Summary

A novel carbon paste electrode modified with magnetite nanoparticles and ionic liquid enhances electroanalytical detection of 17β-estradiol and estriol. This method offers a sensitive and accurate approach for monitoring these potential endocrine disruptors.

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Area of Science:

Electrochemistry
Analytical Chemistry
Materials Science

Background:

17β-estradiol and estriol are significant endocrine disruptors requiring effective monitoring methods.
Developing sensitive and selective electroanalytical devices is crucial for environmental and pharmaceutical analysis.

Purpose of the Study:

To develop and characterize a novel carbon paste electrode modified with magnetite nanoparticles and ionic liquid for the electroanalytical determination of 17β-estradiol and estriol.
To optimize square-wave voltammetry parameters using Box-Behnken design for enhanced sensitivity and accuracy.

Main Methods:

Fabrication of a carbon paste electrode modified with magnetite nanoparticles and 1-butyl-3-methylimidazolium hexafluorophosphate.
Characterization of modified materials using Transmission Electron Microscopy, Scanning Electron Microscopy, and Zeta Potential.
Electrochemical analysis via cyclic voltammetry and square-wave voltammetry, with optimization using Box-Behnken factorial design.

Main Results:

The modified electrode exhibited irreversible oxidation peaks for 17β-estradiol (+0.320 V) and estriol (+0.400 V).
Anodic currents were significantly enhanced (approximately threefold) compared to the unmodified electrode, indicating improved sensitivity.
Achieved detection limits of 50.0 nmol L⁻¹ for 17β-estradiol and 300.0 nmol L⁻¹ for estriol.
Linear calibration ranges were established from 0.10 to 1.0 μmol L⁻¹ for 17β-estradiol and 1.0 to 10.0 μmol L⁻¹ for estriol.

Conclusions:

The developed modified electrode provides a sensitive and reliable platform for the electroanalytical determination of 17β-estradiol and estriol.
The method demonstrated comparable accuracy and precision to UV/VIS spectrometry when applied to pharmaceutical formulations.
This approach offers a promising tool for monitoring endocrine-disrupting estrogens in various samples.