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Metabolic Syndrome in HIV/HCV Co-infected Patients

Lauren F Collins1, Ruth O Adekunle1, Emily J Cartwright1,2

  • 1Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.

Current Treatment Options in Infectious Diseases
|February 8, 2020
PubMed

Insights

Patients with HIV and HCV co-infection face a higher risk of metabolic syndrome due to patient factors, viral effects, and antiretroviral therapy (ART). Further research is needed for better screening and treatment strategies.

Area of Science:

  • * Infectious Diseases
  • * Cardiovascular Medicine
  • * Metabolic Disorders

Background:

  • * HIV/HCV co-infection presents a significant burden of metabolic syndrome.
  • * This population experiences elevated cardio-metabolic risk due to a complex interplay of factors.

Purpose of the Study:

  • * To review the scope and burden of metabolic syndrome in HIV/HCV co-infected patients.
  • * To identify risk factors and mechanisms contributing to cardio-metabolic risk.
  • * To discuss clinical management strategies in the context of modern therapies.

Main Methods:

  • * Comprehensive literature review of studies on metabolic syndrome in HIV/HCV co-infected individuals.
  • * Analysis of patient-specific factors, viral effects, and antiretroviral therapy (ART) impacts.
  • * Examination of emerging evidence on direct-acting antivirals (DAAs) for HCV eradication.

Main Results:

  • * HIV/HCV co-infection elevates metabolic syndrome risk through patient factors, viral effects, and ART exposure.
  • * Chronic infection triggers inflammation, altering glucose and lipid metabolism.
  • * ART selection requires careful consideration of metabolic side effects like dyslipidemia and weight gain.

Conclusions:

  • * Metabolic derangements in HIV/HCV co-infection are multifactorial.
  • * Eradication of HCV with DAAs may improve metabolic health, but requires further study in co-infected patients.
  • * Future research should focus on enhanced screening, treatment, and prevention of metabolic syndrome in this population.
Abstract

Keywords:
Human immunodeficiency virusage-associated comorbiditiesantiretroviral therapychronic hepatitis C virusdirect-acting antiviralsmetabolic syndrome

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