Dengue: Update on Clinically Relevant Therapeutic Strategies and Vaccines

Area of Science:

• * Virology and Infectious Diseases
• * Public Health and Epidemiology
• * Vaccinology and Pharmacology

Background:

• * Dengue viruses (DENV) are a significant global health concern, with four distinct serotypes causing potentially severe illness.
• * Current dengue management relies primarily on supportive care, and existing vaccines have limitations.
• * There is a critical need for effective therapeutics and vaccines to reduce dengue morbidity and mortality.

Purpose of the Study:

• * To review the current standard-of-care for dengue treatment.
• * To highlight recent advancements in emerging dengue therapeutics and vaccines.
• * To discuss drugs and vaccines in various stages of preclinical and clinical development.

Main Methods:

• * Comprehensive literature review of current and emerging dengue treatments.
• * Analysis of preclinical and clinical data for novel antiviral drugs and vaccine candidates.
• * Synthesis of information on host-targeted therapies and direct antivirals.

Main Results:

• * Advances include direct-acting antivirals targeting viral replication.
• * Host-targeted therapies are being developed to mitigate inflammation and vascular complications.
• * Several new vaccine candidates are undergoing evaluation for safety and efficacy.

Conclusions:

• * Emerging therapeutics and vaccines show promise in addressing the limitations of current dengue management.
• * Continued research and development are crucial for effective dengue control and prevention.
• * Novel treatment strategies are essential to reduce the global burden of dengue virus infections.