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A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
Published on: June 24, 2020
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Chorioamnionitis: Establishing a correlation between clinical and histological diagnosis
1Department of Pathology, College of Medicine, King Saud University, Riyadh 12372, Saudi Arabia.
Indian Journal of Pathology & Microbiology
|February 8, 2020
Summary
Clinical diagnosis for chorioamnionitis is often inaccurate, missing most cases. Maternal and fetal tachycardia showed the most promise among clinical indicators for diagnosing this pregnancy complication.
Area of Science:
- Perinatal Medicine
- Obstetrics
- Pathology
Background:
- Chorioamnionitis poses significant risks for maternal and infant morbidity and mortality.
- Early diagnosis of chorioamnionitis is crucial for effective treatment.
- Conflicting views exist regarding the diagnostic accuracy of clinical versus histological methods for chorioamnionitis.
Purpose of the Study:
- To evaluate the accuracy of clinical diagnoses of chorioamnionitis.
- To compare clinical diagnosis with histopathological findings.
- To identify reliable clinical indicators for chorioamnionitis.
Main Methods:
- Retrospective review of 696 placental records from single and multiple pregnancies.
- Analysis of histological data for the presence of chorioamnionitis.
- Assessment of the sensitivity and accuracy of clinical diagnoses.
Main Results:
- Histological evidence of chorioamnionitis was found in 52.9% of cases with available data (135 out of 255).
- Clinical diagnosis of chorioamnionitis demonstrated low sensitivity (26.7%) and accuracy (61.1%).
- Clinical indicators failed to identify 73.3% of histologically confirmed chorioamnionitis cases.
Conclusions:
- Clinical diagnosis of chorioamnionitis is unreliable and frequently inaccurate.
- The majority of histologically confirmed chorioamnionitis cases were missed by clinical assessment.
- Maternal and fetal tachycardia emerged as the most dependable clinical indicators for chorioamnionitis.
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