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Increased urinary excretion of glycosaminoglycans in insulin-dependent diabetic patients with limited joint mobility
G C Priestley1, A Collier, D M Matthews
1University Department of Dermatology, Royal Infirmary, Edinburgh, Scotland.
Abstract:
Urinary excretion of glycosaminoglycans (GAG) was measured in 24-h specimens collected from 27 insulin-dependent male diabetic patients and 22 healthy males of similar ages. Excretion relative to creatinine was increased by 35% in the diabetic group as a whole (p less than 0.02). Twelve patients with limited joint mobility (cheiroarthropathy) formed a subgroup with high excretion (69% above controls), those without limited joint mobility being similar to controls. There was no correlation of retinopathy with GAG excretion.
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