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Updated: Dec 29, 2025

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Vitamin C Deficiency-Induced Pulmonary Arterial Hypertension
Shameek K Gayen1, Abd A Abdelrahman2, Ioana R Preston2
1Department of Internal Medicine, Tufts Medical Center, Boston, MA.
Abstract:
We report a case of a man in his 60s who developed pulmonary arterial hypertension (PAH) in association with profound vitamin C deficiency. Decreased availability of endothelial nitric oxide and activation of the hypoxia-inducible family of transcription factors, both consequences of vitamin C deficiency, are believed to be mechanisms contributing to the pathogenesis of the pulmonary hypertension. The PAH resolved following vitamin C supplementation. The current case highlights the importance of testing for vitamin C deficiency in patients with PAH in the proper clinical setting.
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