Related Experiment Video
Updated: Dec 29, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Increasing the documentation of 48-hour antimicrobial reviews
Ramandeep Singh Sahota1, Kiran Kasper Rajan2, Jonathan Mark Sabine Comont2
1Medical School, GKT School of Medicine, London, UK ramandeep.sahota@kcl.ac.uk.
Abstract:
Antimicrobial resistance is a growing problem worldwide. Encouraging antimicrobial stewardship can help to reduce the negative consequences of inappropriate antibiotic use. This quality improvement project targets to do this by aiming to improve the proportion of 48-hour antimicrobial reviews completed and documented on two surgical wards at Darent Valley Hospital with a goal of 100% compliance.This project used four PDSA (plan, do, study, act) cycles to achieve our aim: a trust-wide email; education sessions with junior doctors; sticker reminders in patient notes; presenting our study to surgical consultants and displaying posters on the wards.The proportion of antimicrobial reviews completed at 48 hours in the patient notes increased from 18% to 77% over 19 weeks from 10 October 2018 to 20 February 2019. The most successful intervention was providing a presentation for consultants at an audit meeting in conjunction with displaying posters on the wards.The most successful interventions (education sessions with junior doctors and presentation to surgical consultants alongside displaying posters on the wards) were found to be those that required minimal further input after their initial rollout. This project was carried out by medical students and is highly transferrable to other hospitals, and highlighted that a successful quality improvement project can be undertaken by any member of the healthcare team.
Insights
Antimicrobial stewardship improves antibiotic review compliance. A quality improvement project increased 48-hour antimicrobial reviews from 18% to 77% through targeted interventions.
Area of Science:
- Healthcare Quality Improvement
- Infectious Diseases
- Pharmacology
Background:
- Antimicrobial resistance (AMR) is a significant global health threat.
- Inappropriate antibiotic use exacerbates AMR and its consequences.
- Effective antimicrobial stewardship programs are crucial to mitigate these risks.
Purpose of the Study:
- To enhance the completion rate of 48-hour antimicrobial reviews on surgical wards.
- To achieve 100% compliance in documenting these critical reviews.
- To implement and evaluate interventions within a quality improvement framework.
Main Methods:
- Utilized four Plan-Do-Study-Act (PDSA) cycles for iterative improvement.
- Implemented interventions including trust-wide emails, junior doctor education, patient note stickers, consultant presentations, and ward posters.
- Monitored the proportion of 48-hour antimicrobial reviews over a 19-week period.
Main Results:
- The proportion of completed 48-hour antimicrobial reviews increased from 18% to 77%.
- The most effective interventions involved consultant presentations and ward posters.
- Interventions requiring minimal post-rollout input demonstrated greater success.
Conclusions:
- Targeted quality improvement initiatives can significantly improve antimicrobial stewardship practices.
- Collaborative efforts, including medical student-led projects, can yield substantial improvements.
- Successful strategies are often those that are easily integrated into existing workflows.
More Related Videos
12:08Rapid Antimicrobial Susceptibility Testing by Stimulated Raman Scattering Imaging of Deuterium Incorporation in a Single Bacterium
Published on: February 14, 2022
09:59Application of the Intelligent High-Throughput Antimicrobial Sensitivity Testing/Phage Screening System and Lar Index of Antimicrobial Resistance
Published on: July 21, 2023
Related Concept Videos
Antimicrobial Effectiveness
Pharmacovigilance
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
Drug Regulation
Antibiotic Selection
Antimicrobial Proteins
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Development of Antibiotic Resistance