Related Experiment Video
Updated: Dec 29, 2025
10:08
Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine
Published on: February 17, 2018
13.9K
Synchronized Biventricular Heart Pacing in a Closed-chest Porcine Model based on Wirelessly Powered Leadless
Hongming Lyu1, Mathews John2, David Burkland3
1Electrical and Computer Engineering Department, University of California Los Angeles, 420 Westwood Plaza, Los Angeles, CA, 90095, USA.
Scientific Reports
|February 9, 2020
Summary
This study introduces leadless biventricular pacing using wirelessly powered pacemakers in a porcine model. This novel approach offers a promising solution for cardiac resynchronization therapy, improving heart function without traditional wires.
Area of Science:
- Biomedical Engineering
- Cardiovascular Technology
- Implantable Devices
Background:
- Ventricular dyssynchrony affects 30% of patients with impaired cardiac function, necessitating cardiac resynchronization therapy (CRT).
- Traditional CRT systems rely on transvenous leads, which carry risks of complications and limitations.
Purpose of the Study:
- To demonstrate synchronized biventricular pacing in a leadless fashion using miniaturized, wirelessly powered pacemakers.
- To evaluate the feasibility and efficacy of leadless biventricular pacing in a preclinical model.
Main Methods:
- Implantation of two epicardially placed, wirelessly powered pacemakers on the right and left ventricles of a porcine model.
- Inductive powering using industrial, scientific, and medical (ISM) bands at 13.56 MHz and 40.68 MHz.
- Assessment of electrophysiologic and hemodynamic responses to varying interventricular delays in both open-chest and closed-chest settings.
Main Results:
- Successful demonstration of leadless biventricular pacing in both open-chest and closed-chest porcine models.
- Novel integrated circuit design achieved µW-level power consumption, extending operating distance.
- Closed-chest pacing required low external power (0.3 W and 0.8 W) with specific absorption rates significantly below safety limits.
Conclusions:
- This study establishes a foundation for future wirelessly powered leadless pacemakers.
- Leadless biventricular pacing offers a viable alternative for addressing cardiac resynchronization challenges.
- The technology shows potential for safer and more effective CRT delivery.
