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Updated: Dec 29, 2025
08:32
Genome-Wide CRISPR Screen for Unveiling Radiosensitive and Radioresistant Genes
Published on: May 23, 2025
979
Combining omics technologies with CRISPR-based genome editing to study food microbes.
Meichen Pan1, Rodolphe Barrangou1
1Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, Raleigh, NC, USA; Genomic Sciences Graduate Program, North Carolina State University, Raleigh, NC, USA.
Current Opinion in Biotechnology
|February 9, 2020
Summary
Omics technologies and CRISPR gene editing are revolutionizing food microbiology. Integrating these tools enables precise engineering of microbes for improved probiotics, biotherapeutics, and food fermentation.
Area of Science:
- Microbiology
- Genomics
- Biotechnology
Background:
- Omics technologies (genomics, proteomics, transcriptomics) have advanced microbiome understanding.
- CRISPR-Cas systems offer powerful tools for precise genome editing in microorganisms.
Purpose of the Study:
- To highlight applications of omics and CRISPR in food microbiology.
- To discuss the integration of omics and CRISPR for microbial engineering.
Main Methods:
- Review of omics technologies in food microorganisms.
- Analysis of CRISPR-based genome editing in bacteria.
- Discussion of integrated omics and CRISPR approaches.
Main Results:
- Omics provide functional insights into microbial roles in food.
- CRISPR enables targeted genetic modification of food microbes.
- Integration facilitates enhanced probiotic and biotherapeutic development.
Conclusions:
- Combining omics and CRISPR accelerates engineering of food microbes.
- This synergy drives innovation in probiotics, biotherapeutics, and food fermentation.
- Future applications include tailored microbiome formulation for the food supply chain.
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