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Updated: Dec 29, 2025

Sequential Extraction of Soluble and Insoluble Alpha-Synuclein from Parkinsonian Brains
Published on: January 5, 2016
[Perspective of α-synuclein and Familial Parkinson's Disease]
Kenya Nishioka1, Nobutaka Hattori
1Department of Neurology, Juntendo University School of Medicine.
Abstract:
To date, there have been several reports about the genes associated with familial Parkinson's disease. These genes are classified following the PARK nomenclature. The prevalence of these genes varies between countries. Moreover, each gene is associated with different symptoms during disease progression. In this review, we will summarize the clinical findings and molecular functions, with a focus on alpha-synuclein, along with recent discoveries and will try to associate them with sporadic Parkinson's disease.
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