Related Experiment Video
Updated: Dec 29, 2025
09:37
A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
Published on: July 14, 2016
8.7K
Mouse Systems Genetics as a Prelude to Precision Medicine
1Laboratory of Integrative Systems Physiology, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland.
Trends in Genetics : TIG
|February 11, 2020
Summary
Mouse models are crucial for disease research but have limitations in human application. Systems genetics offers a way to improve mouse models for better precision medicine development.
Area of Science:
- Genetics
- Translational Medicine
- Systems Biology
Background:
- Mouse models are essential tools for studying human diseases and testing potential treatments.
- Controlled environments and genetics in mouse models enhance research rigor but limit real-world applicability.
- Current mouse model strategies need refinement for precision medicine in diverse human populations.
Purpose of the Study:
- To review current resources in mouse systems genetics.
- To discuss how mouse systems genetics aids in understanding human diseases.
- To explore the advancement of precision medicine through mouse systems genetics.
Main Methods:
- Review of existing literature and resources.
- Analysis of systems genetics approaches in mouse models.
- Discussion of strategies for enhancing translatability to human medicine.
Main Results:
- Mouse systems genetics provides valuable insights into complex human diseases.
- This approach helps bridge the gap between preclinical research and clinical application.
- Numerous resources and strategies are available to advance precision medicine.
Conclusions:
- Systems genetics in mouse models is a powerful paradigm for precision medicine.
- Further development and application of these resources can accelerate therapeutic discoveries.
- Revisiting mouse model strategies is key to achieving effective human health outcomes.
Related Concept Videos
02:43Mouse Models of Cancer Study
6.3K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
6.3K
02:46Genetic Screens
5.5K
Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
5.5K
01:28Human Genetics
1.3K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
1.3K
01:43Incomplete Dominance
29.5K
Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
29.5K
01:16In-vitro Mutagenesis
15.9K
To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
15.9K