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Updated: Dec 28, 2025

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
Cobalt(I)-Catalyzed Borylation of Unactivated Alkyl Bromides and Chlorides
Piyush Kumar Verma1, K Sujit Prasad1, Dominic Varghese1
1Department of Inorganic and Physical Chemistry , Indian Institute of Science , Bangalore 560012 , India.
Abstract:
A cobalt-complex-catalyzed borylation of a wide range of alkyl halides with a diboron reagent (B2pin2 or B2neop2) has been developed under mild reaction conditions, demonstrating the first cobalt-mediated cross-coupling with alkyl electrophiles. This protocol allows alkyl boronic esters to be accessed from alkyl halides, including alkyl chlorides, which were used rarely as coupling partners. Mechanistic studies reveal the possible involvement of an alkyl radical intermediate in this cobalt-mediated catalytic cycle.
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