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Desensitizing Toothpastes for Dentin Hypersensitivity: A Network Meta-analysis.

C C Martins1,2, R T Firmino1,2, J J Riva1,3

  • 1Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.

Journal of Dental Research
|February 11, 2020
PubMed
Summary
This summary is machine-generated.

This systematic review found that several toothpaste ingredients effectively treat dentin hypersensitivity (DH). Calcium sodium phosphosilicate (CSP) offered the most consistent benefits across all stimuli, outperforming standard fluoride treatments.

Keywords:
dentifricesdentine sensitivitydentistrypainsystematic reviewtherapeutics

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Area of Science:

  • Dental Science
  • Pharmacology
  • Clinical Trials

Background:

  • Dentin hypersensitivity (DH) is a common condition.
  • Effective toothpaste formulations are crucial for managing DH pain.
  • Randomized controlled trials (RCTs) provide evidence for treatment efficacy.

Purpose of the Study:

  • To compare the relative effectiveness of various toothpaste formulations for dentin hypersensitivity (DH).
  • To analyze results from randomized controlled trials (RCTs) using network meta-analysis.
  • To assess the certainty of evidence for different active ingredients.

Main Methods:

  • Systematic review and Bayesian network meta-analysis of 125 RCTs (12,541 patients).
  • Data extracted on painful responses to tactile, cold, and air stimuli.
  • Standardized mean difference (SMD) and Grading of Recommendations, Assessment, Development and Evaluation (GRADE) used for analysis.

Main Results:

  • Calcium sodium phosphosilicate (CSP) showed significant benefits for all three stimuli (tactile, cold, air) compared to fluoride.
  • Stannous fluoride (SnF2) alone and combined with potassium or hydroxyapatite were effective for tactile and air stimuli.
  • Arginine, strontium, and potassium also demonstrated benefits for specific stimuli.

Conclusions:

  • Most tested toothpaste formulations are superior to placebo or standard fluorides for DH.
  • CSP is the most beneficial ingredient across all stimuli.
  • Specific formulations containing CSP, SnF2, arginine, strontium, or potassium offer effective DH management.