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Updated: Dec 28, 2025
07:16
Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
Published on: September 13, 2018
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The Hippo Pathway and Viral Infections
Zhilong Wang1, Wanhang Lu1, Yiling Zhang1
1College of Chemistry and Life Sciences, Zhejiang Normal University, Jinhua, China.
Frontiers in Microbiology
|February 11, 2020
Summary
The Hippo signaling pathway, a tumor suppressor, is crucial in organ size, cell growth, and cancer. This review details its role in virus infection and pathogenesis.
Area of Science:
- Molecular Biology
- Oncology
- Virology
Background:
- The Hippo signaling pathway is a conserved tumor suppressor pathway.
- It regulates organ size, cell proliferation, and development.
- Dysregulation is linked to cancer and other diseases.
Purpose of the Study:
- To review the biological features and pathological roles of the Hippo pathway.
- To focus on the pathway's function in viral infections and pathogenesis.
Main Methods:
- Literature review of current research on the Hippo signaling pathway.
- Synthesis of findings related to its role in biological processes and disease.
Main Results:
- The Hippo pathway is vital for controlling organ size and preventing uncontrolled cell proliferation.
- Emerging evidence highlights its significant role in the pathogenesis of virus-induced diseases.
Conclusions:
- The Hippo pathway is a key regulator with implications beyond cancer, extending to viral pathogenesis.
- Further research into the Hippo pathway's role in virology may reveal new therapeutic targets.
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