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Updated: Dec 28, 2025

Application of Genetically Encoded Fluorescent Nitric Oxide (NO•) Probes, the geNOps, for Real-time Imaging of NO• Signals in Single Cells
Published on: March 16, 2017
Recent Advances in Fluorescent Probes for Detection of HOCl and HNO
Anila Hoskere Ashoka1, Firoj Ali2, Rajeshwari Tiwari3
1Laboratoire de Bioimagerie et Pathologies, UMR 7021 CNRS, Facultéde Pharmacie, Universitéde Strasbourg, Strasbourg, CS 60024, France.
Abstract:
It is known that reactive oxygen (ROS) and nitrogen (RNS) species play a diverse role in various biological processes, such as inflammation, signal transduction, and neurodegenerative injury, apart from causing various diseases caused by oxidative and nitrosative stresses, respectively, by ROS and RNS. Thus, it is very important to quantify the concentration level of ROS and RNS in live cells, tissues, and organisms. Various small-molecule-based fluorescent/chemodosimetric probes are reported to quantify and map the effective distribution of ROS/RNS under in vitro/in vivo conditions with a great spatial and temporal resolution. Such reagents are now appreciated as an excellent tool for aiding breakthroughs in modern redox biology. This mini-review is a brief, but all-inclusive, account of such molecular probes that have been developed recently.
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